Vaccines are on everyone’s mind in 2020. We are fortunate that initial testing of COVID-19 vaccines has yielded encouraging outcomes. This has not been the case for malaria vaccines, for which scientists worldwide have also spent considerable effort on developing. For reasons that have eluded us, our best malaria vaccines are inefficient. I previously wrote about how the antibody response to malaria infection is atypical. Here, I explore new research that explains how these antibody responses interfere with long-term protection from malaria parasites.